FHIR Chat · Joint openEHR meeting, November

Stream: genomics

Topic: Joint openEHR meeting, November

Grahame Grieve (Jun 10 2019 at 14:19):

The openEHR community has asked whether we (FHIR community) are interested in a doing a joint FHIR / openEHR meeting around alignment in the genomics space somewhere in Europe as a satellite meeting to DevDays in Amsterdam

Grahame Grieve (Jun 10 2019 at 14:21):

with regard to their interest in genomics, there is ongoing work about the modelling of genetic variant archetypes with openEHR, and @Ian McNicoll says:

The rationale is that this can lead to broader international input on the genomics models (and from a wider perspective than just reporting) and that there is a bunch of prior art in terms of clinical phenotypics- both from HighMED and Genomics England use and while this may not be immediately applicable but should at least act as a kick-off point for discussion and development. The prime goal here is not to be offering an alternative set of models but examining if/how using openEHR methodology can get us to the same GA4GH endpoint more efficiently. We have to cover the same sort of ground internally, in any case.

Jim Steel (Jun 10 2019 at 17:52):

We (CSIRO, not me specifically) are certainly interested and active in that space. @Alejandro Metke would be the most obvious person to participate in that, but he won't be able to be at DevDays as he'll be at AMIA. We might try to send someone else though

Liz Amos (Jun 11 2019 at 14:45):

From Clem McDonald: Need to distinguish between reporting of genetic reports to clinicians from the reporting of raw results from sequencing (different approaches). Some standards are established for sequencing results. Also be aware of active work on phenotyping from the Monarch Initiative (https://monarchinitiative.org/) and the eMERGE study, both funded by NHGRI/NIH.

Ian McNicoll (Jun 12 2019 at 12:39):

The primary focus here is on genetic reports to clinicians. https://openehr.org/ckm/templates/1013.26.223 but also within the context of a rich phenotypics dataset e.g. https://ckm.apperta.org/ckm/#showProject=1051.61.28 - this is currently being used in a number of UK hospitals to gather front-line data and curate it before reporting. Just to be clear our goal in this new project is to sit inside the GA4GH output, in terms of exchanging data but see if/how using openEHR can help in the definition of genomics variant models for persistence in an EHR, as well as being a basis for the very extensive FHIR profiling work that will be required for the clinical phenotypics.

Birger (Jun 13 2019 at 09:18):

I think this would also be of interest for the German HiGHmed consortium! So also a +1 from my side

Patrick Werner (Jun 13 2019 at 09:46):

depending on actual date and location this could be interesting to us

GIanluigi Zanetti (Jun 22 2019 at 20:23):

Hi! we (CRS4) will be definitely interested in participating.

Bob Milius (Jun 27 2019 at 21:03):

@Bob Freimuth

Bret H (Sep 20 2019 at 16:43):

Echo Clem's comment on identifying the specific use cases. Clinical reporting is a different endpoint than enabling reanalysis or research. @Bob Freimuth given the modeling aspects, I would recommend Bob Freimuth be requested to participate. He leads or Information Modeling subgroup.

Mark Kramer (Sep 20 2019 at 16:47):

@Ian McNicoll I would be interested in attending such a meeting. I work on the mCODE (minimal Cancer Oncology Data Elements) project, which up to now, has been US-focused. But we realize there is a demand for an international standard and want to work towards that.

Bret H (Sep 24 2019 at 20:57):

@Patrick Werner did the meeting already take place? I realize Grahame was talking about DevDays. Was there documentation of the outcome from the meeting?