Stream: implementers
Topic: DrugDrug-Interactions
Nathan Hall (Oct 26 2018 at 19:15):
What is the preferred resource type and data parameters to send back for drug drug interactions? If someone where to send me a list of ndcs or rxcuis, what endpoint would I have them hit? How would I structure a response from that end point if I have 2 drugs with rxcuis and message of text that describes the interaction?
Jose Costa Teixeira (Oct 26 2018 at 20:45):
@Rik Smithies @Melva Peters
Jose Costa Teixeira (Oct 26 2018 at 20:46):
i think that there should be a construct in FHIR for this kind of things. Indicated for, contraindicated with.... I don't know enough to see if there is anything that while specific would cover 80% of the cases.
Jose Costa Teixeira (Oct 26 2018 at 20:47):
but Pharm and BRR are looking at resources to define a medicinal product, that discussion does contain the information you look for
Rik Smithies (Oct 27 2018 at 13:53):
Currently this can be use the draft resource MedicinalProductInteraction. See http://build.fhir.org/medicinalproductinteraction.html. We would definitely be interested to know if this resource covers what you want. It is modelled based on what is needed for the ISO IDMP standard.
Nathan Hall (Oct 29 2018 at 13:28):
that's perfect. thank you.
Andrew Gledhill (Oct 29 2018 at 17:33):
Hello Rik. An important factor in medication interactions is the 'severity' of the interaction. In the UK this is defined by four levels of severity: 1 - 4 with 4 being the most severe i.e. a contra-indication. Can the interaction severity be easily recorded using the current interaction definition structure? Thanks and regards. Andrew
Rik Smithies (Oct 30 2018 at 16:53):
Hi @Andrew Gledhill , there is MedicinalProductInteraction.effect which can use any set of codes. So that could possibly be "interaction of severity 1", "interaction of severity 2" etc, or whatever the appropriate text is. But I think it may be reasonable to add a specific "severity" attribute. We would need to be careful to distinguish between effect (which could include a severity) and a dedicated severity. Any ideas here of how a range of systems typically record potential effects and or severity would be helpful here. The IDMP concept of Interaction.effect is more specific than severity, such as "gastric absorption of primary medication impaired".
Brian Postlethwaite (Oct 31 2018 at 00:44):
And how interoperable a coded severity could be.
Brian Postlethwaite (Oct 31 2018 at 00:44):
And if that is expected to be able to be ordered
Robert McClure (Nov 09 2018 at 00:19):
@Russell Leftwich
Last updated: Apr 12 2022 at 19:14 UTC
